منابع مشابه
Neoplastic development ie B-Iymplhocytes
Neoplastic transformation is a complex process that results from multiple changes in gene activities. Probably most of these are mutational, i.e. alterations in the genomic structure of DNA, but others may be due to adaptive changes wherein genes are expressed that are inappropriate to a stage of development or differentiation. In this commentary neoplastic development is discussed in the conte...
متن کاملMultiple etiologic factors in neoplastic development.
The detailed analysis of mammary neoplasia in inbred mice has disclosed 3 important etiologic factors, compris ing, as stated in Bittner's 3-factor hypothesis, a genetic factor, a hormonal factor, and a milk-borne tumor agent with the properties of a virus and now usually called the milk agent or the Bittner virus. Within certain limits, an excess of one factor can compensate for deficiency in ...
متن کاملSelected cell and selective microenvironment in neoplastic development.
Recent analysis of genetic alterations in human cancer points to a major role for selection in neoplastic development but provides few details about the dynamics of the process. Many such details, however, have emerged from quantitative studies of spontaneous transformation among mammalian cells in culture. The chief insight of these studies is that there is a continuous generation of variants ...
متن کاملAbove the borderland between normal and neoplastic development.
This dialogue between the Editor-in-Chief of the Int. J. Dev. Biol. and a leading figure in human pathology and mammalian embryology highlights the close links between the biological interpretation of neoplasia and differentiation processes which normally occur during development, particularly in the case of teratomas. In addition, it emphasizes how a capacity for work, a firm will to progress,...
متن کاملDynamics of neoplastic development in carcinogen-exposed tracheal mucosa.
The qualitative and quantitative cellular changes occurring in trachéalepithelium in vivo during the process of carcinogenesis were investigated by use of an in vitro assay which mea sures the formation of epithelial foci (EF); this method is called EF assay. The cell or cells giving rise in vitro to an EF which survives and proliferates for at least 1 month after trachéal cells have been see...
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ژورنال
عنوان ژورنال: Nature
سال: 1976
ISSN: 0028-0836,1476-4687
DOI: 10.1038/259429c0